A new study has found females and minorities have a greater risk of restenosis and subsequent MACE than “white” men after receiving everolimus-eluting stent implantation.
The Study Setup
A cohort study that pulled thousands of patients from both the PLATINUM Diversity and PROMUS Element Plus Post-Approval looked at groups of men, women and minorities to evaluate how each fared after undergoing percutaneous coronary intervention (PCI).
Patients were enrolled in the trial and were followed for a year after the implantation of at least one drug-eluting stent. Major adverse cardiac events, which included death, myocardial infarction and target vessel revascularization, and secondary ischemic endpoints were taken into account.
The Study Findings
One-year outcome rates for major adverse cardiovascular events were similar between the study cohorts. However, the adjusted risk of death and MI was higher among women and minorities.
At baseline, women and minorities had past medical history of common comorbidities like:
- renal disease
- congestive heart failure
Caucasian men in the study, the authors reported, had a lower prevalence of smoking, multi-vessel disease, prior coronary artery bypass graft surgery and prior myocardial infarction (MI).
The Study Takeaway
“Our data suggest that differential risks of thrombosis or atherosclerosis contribute more to this phenomenon than stent failure,” study authors say “In providing a comprehensive evaluation of the impact of race/ethnicity, sex and social determinants of health on contemporary PCI outcomes, this study contributes significantly to our current knowledge base.”
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